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Figure 7-1 Rearrangements of antigen receptor genes and lineage choices during lymphoid development
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Figure 7-2 Germline structure of immunoglobulin and TCR genes
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Figure 7-3 Ordered rearrangement of gene segments to create a functional Ig heavy-chain-encoding gene
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Figure 7-4 Recombination signal sequences
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Figure 7-5 Discovery of RAG-1 and RAG-2
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Figure 7-6 Mechanism of V(D)J recombination
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Figure 7-7 Processing of coding ends to generate junctional diversity
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Figure 7-8 Ontological control of V gene usage in γδ T cell development
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Figure 7-9 Feedback control of V(D)J recombination in B cell and T cell development
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Figure 7-10 Pre-BCR structure and function
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Figure 7-11 Successive rearrangements at the TCR α locus allow multiple α chains to be tested in conjunction with a single TCR β chain until positive selection occurs
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Figure 7-12 Evolution of major features of adaptive immunity
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Figure 7-13 Shark IgH locus organization
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Figure 7-14 Chicken Ig gene diversification by gene conversion
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Figure 7-15 Control of B cell development by a cascade of transcription factors
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Figure 7-16 Phenotypic properties of B-lineage developmental intermediate cell types
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Figure 7-17 Receptor editing of the Igκ locus
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Figure 7-18 Effect of BCR signaling strength on fate of immature and transitional B cells
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Figure 7-19 Impact of antigen receptor signaling mutations on maturation of B cell subsets
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Figure 7-20 BAFF and its receptors on B cells
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Figure 7-21 Organization of the thymus
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Figure 7-22 Stages in the development of αβ T cells
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Figure 7-23 αβ versus γδ T cell lineage choice
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Figure 7-24 Different fates of double-positive thymocytes
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Figure 7-25 Self peptides that cause positive selection
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Figure 7-26 Original models to explain CD4/CD8 lineage choice
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Figure 7-27 Recent models to explain CD4/CD8 lineage choice
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Figure 7-28 Table of mutations causing defects in negative selection and leading to autoimmunity
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Figure 7-29 Autoimmunity to multiple organs in mice deficient in Aire
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Figure 7-30 Kinetic signaling model for discrimination between negatively selecting peptides and positively selecting peptides
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Figure 7-31 Table of genetic defects in human immunodeficiencies
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Figure 7-32 Chromosome translocation activating Myc
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Figure 7-33 Table of oncogenic translocations caused by V(D)J recombination errors
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