New Science Press | Primers | Immunity: The Immune Response in Infectious and Inflammatory Disease

Updated sections are provided separately from the original text which is still accessible in its unrevised form. For instructors using this resource for teaching, we have suggestions on how the currently available new sections should be integrated with the text for students.

Updates to date
Imaging and tracking immune responses
Epstein–Barr virus
Malaria

2007-2008 - Updated references for the whole text


2007-2008 Updates
	Tracking immune responses in vivo U5-1 Detecting and Analyzing T Cell Responses (Chapter 5)
	U5-2 Real-Time Imaging of T Cell Signaling Events (Chapter 5)
	U5-3 Imaging Lymphocytes In Situ (Chapter 5)
	Epstein–Barr virus U10-1 Epstein–Barr Virus (EBV) (Chapter 10)
	Malaria U11-1 Malaria (Chapter 11)

Updates – 2007-2008

Chapter 5: Activation and Effector Actions of T Cells

Tracking immune responses in vivo

U5-1 Detecting and Analyzing T Cell Responses [Full Text] [PDF]
-T cell responses can be tracked using transgenic mice and MHC tetramers
-Mice carrying introduced genes are an important source of large numbers of T cells with defined specificity
-MHC tetramers are important for tracking antigen-specific T cells

U5-2 Real-Time Imaging of T Cell Signaling Events [Full Text] [PDF]
-Imaging techniques allow lymphocyte interactions to be studied in whole cells and tissues
-Molecular events in T cell activation can be followed in intact single cells
-The molecular events at the immunological synapse can be inferred from model systems

U5-3 Imaging Lymphocytes In Situ [Full Text] [PDF]
-Localization of lymphocytes in organs can be determined by antibody staining
-Lymphocyte interactions in vivo can be tracked by using fluorescent dyes and real-time two-photon microscopy

Chapter 10: The Immune Response to Viral Infection

Epstein–Barr virus

U10-1 Epstein–Barr Virus (EBV) [Full Text] [PDF]
-EBV is a herpesvirus that causes lifelong infection of B cells
-EBV induces B cell differentiation and establishes latency in memory B cells
-Control of EBV is lost in immunodeficiency

Chapter 11: The Immune Response to Fungal and Parasitic Infection

Malaria

U11-1 Malaria [Full Text] [PDF]
-Malaria is an infection of red cells that is transmitted by mosquitoes
-Plasmodium falciparum causes severe malaria through adherence of infected cells to the microvasculature and by induction of cytokines
-Slow development of malaria immunity reflects antigenic variation