| Figure 4-25 |
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| The method of profile-based threading | |
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| A sequence of unknown structure is forced to adopt all known protein domain folds, and scored for its suitability for each fold. The z-value relates the score for the query sequence to the average score for a set of random sequences with the same amino-acid composition and sequence length. A very high z-score indicates that the sequence almost certainly adopts that fold. Sequences can be submitted online for threading by PSIPRED http://bioinf.cs.ucl.ac.uk/psipred/index.html. |