| The structure at the center is the target, the experimentally determined structure of a homeodomain. The other structures are generated by the Monte Carlo approach in Rosetta, using only the sequence of the protein. Although some of the structures are quite far from the true structure, others are close enough for the fold to be recognizable. Rmsd is the root mean square deviation in α-carbon positions between the computed structure and the experimentally determined structure. (Taken from Simons, K.T. et al.: J. Mol. Biol. 1997, 268:209–225.) |
