…about the book

"...The layout of the chapters is excellent, and the book is easy to read and use as a resource...This reviewer has not encountered a book better than this one for students interested in learning more about structure-function relationships in proteins...Essential. All levels."
The American Library Association's CHOICE magazine

"First, let me say again what a wonderful book this is! It is written just about as well as can be done within the limitations of the English language; it is incredibly clear. And, I think this book certainly hits its mark for the audience it targets."
Ken Dill
Department of Pharmaceutical Chemistry, University of California, San Francisco

…about Chapter 1

"...this chapter covers truly a lot of ground with some insightful depth and cohesion. It is written by two experts in the field who are not afraid to introduce the details of elements of the field in depth, yet cover the paradigms well. In many ways it is a powerful successor to the several books on protein structure... It has certainly moved well beyond the scope of other books."
Robert Stroud
University of California, San Francisco

"I read the outline and sample text [on motifs and classes of domains] with great interest. Overall I think it is just excellent - (in fact it follows almost exactly the same course as my 2nd year lectures on protein structure)."
Janet Thornton
University College London
(Now Director of EBI)

"This [text] focuses on structure and stability, rather than on biological categories, and it does an excellent job of outlining the fundamental themes. It also ties in physical chemistry (through forces and energetics)....We could therefore use it as a basic text in the protein structure plus physical chemistry course we teach for juniors at Harvard"
Stephen Harrison
Harvard University

…about Chapter 2

"A really good book provides a wealth of information in a manner that the reader remembers what he/she has read. This book does just that. The contents just pop into mind from time to time. This book will be a winner."
Tom Bruice
University of California, Santa Barbara

"Overall this looks great! The format is very pleasing to the eye and easy to read. The selection of subsections and topics is excellent."
Karen Allen
Boston University School of Medicine

…about Chapter 3

"I've reviewed the materials that you sent regarding the book from Petsko and Ringe. I'm very excited about what they are putting together. This treatment and focus is much needed. It will be essential reading by students and faculty alike, and will serve as a crucial reference book for everyone in the biosciences."
James Spudich
Stanford University School of Medicine

"I very much liked the Petsko-Ringe signaling section-it covered all the major bases in a thoughtful and coherent way; I'm amazed they managed to make the complexities of signal transduction so intelligible."
Tony Pawson
Samuel Lunenfeld Research Institute

"…well written; easy to read and to follow the descriptions of protein functions. The schematics make the verbal descriptions more understandable."
Richard Silverman
Northwestern University

…about Chapter 4

"It is well-written, makes for interesting reading and contains a number of excellent examples. The whole book appears to be an important, useful and timely one."
Roman Laskowski
European Bioinformatics Institute

"The chapter is extremely well written and very clear. I thoroughly enjoyed reading it."
Jeffrey Skolnick
Danforth Plant Science Center

"I really enjoyed the content and thought the work was generally well written and very timely given the recent explosion of interest in this area."
Michael Snyder
Yale University

…about the 2005-2006 update (Enzyme Kinetics)

"This is an excellent, simple and self-explanatory explanation of enzyme kinetics for undergraduates. Unlike many other treatments of this topic, the present work is instructive, rather than obscuring."
Vernon Schramm
Albert Einstein College of Medicine

…about the 2006-2007 update (Membrane-Associated Enzymes, Ion Channels and Pores)

"...this is an excellent presentation and analysis of the structure and function of membrane proteins, with clear and appropriate descriptions of the structural basis of membrane protein mechanisms. I thought the authors did a great job of summarizing developments in this field."
Douglas Rees
California Institute of Technology

…about the 2007-2008 update (as a special supplement to Chapter 2 - Chapter 3: Principles and Mechanisms of Protein Interactions from Cell Signaling by Lim, Mayer and Pawson)

"Chapter 3 is superb...adopt this ASAP... First, it hits all the key points that I can think of. Second, it hits just the right level - accessible to someone who barely knows what free energy means, but not unduly "downtalking" to someone who knows more. Third, the frequent use of numerical examples in the text is wonderful, as are the tables and diagrams with numbers."
Stephen Harrison
Harvard University

"This is a clear, well written succinct chapter that touches an important aspects of analysing protein–protein interactions from both the thermodynamic underpinnings to some of the common experimental methods. The chapter, in general, is excellent."
Michael Yaffe
Massachusetts Institute of Technology