Wendell Lim graduated in chemistry from Harvard University, and took his PhD in biophysics and biochemistry from the Massachusetts Institute of Technology. He studied protein folding and interactions at Yale University before moving to the University of California, San Francisco, where he is Professor of Cellular and Molecular Pharmacology. The principal focus of his research is on the structure and mechanism of protein interaction domains and the logic by which these components are used to build complex cellular signaling systems.

Bruce Mayer received his undergraduate degree from Wesleyan University and a PhD in Viral Oncology from Rockefeller University. He did postdoctoral work at the Whitehead Institute and Rockefeller University where he developed his interest in the role of modular protein domains in signaling. After his first faculty appointment at Children's Hospital and Harvard Medical School, he moved to his present position at the University of Connecticut Health Center. Current work in his group focuses on characterizing and manipulating tyrosine kinase-mediated signal transduction pathways.

Anthony Pawson graduated in biochemistry from Cambridge University, where he studied under the guidance of Tim Hunt, and at whose suggestion he took his PhD in molecular biology at the Imperial Cancer Research Fund. His postdoctoral research on the v-Fps tyrosine kinase and subsequent work in his own lab at the University of British Colombia lead to the identification of the kinase regulatory domain, which he christened the Src homology 2 (SH2) domain. He is now Senior Investigator and Director of Research in the Department of Medical Genetics and Microbiology at the University of Toronto where his research continues to focus on the molecular dissection and functional significance of protein-protein interactions in signal transduction, and particularly the molecular signals involved in axon guidance and development.