Some of the online update sections for Protein Structure and Function are completely new; others are revised and/or expanded versions of existing sections. Our suggestions on how they best fit with the original text are listed below.

U1-1 and U1-2 – Secondary Structure
The two revised sections on secondary structure can be used to replace the existing sections, 1-5 and 1-8.

U1-3 to U1-5 – Protein Folding
The revised section on folding and the new sections on chaperones and protein folding diseases will be more easily understood if read after Chapter 3, because the section on chaperones depends on some familiarity with the concept of conformational changes driven by nucleotide hydrolysis and the section on folding diseases makes reference to the proteasome. These sections could be taught together with sections 4-14 and 4-15 from Chapter 4, which discuss chameleon sequences and prion and amyloid diseases.

U1-6 to U1-15 – Membrane Proteins
The new sections on membrane protein structure and function extend section 1-11 on membrane protein structure, and add examples of conformational changes underlying ion transport across membranes to the coverage of protein functions in Chapter 2.
(New for 2007–2008  Note that the sections on Active Transport, added in the 2006–2007 update, have been revised for the 2007–2008 update to reflect more recent developments.)

U2-1 to U2-4 – Enzyme Kinetics
The new sections on enzyme kinetics can be used after section 2-6, an overview of catalysis, and to supplement the subsequent Chapter 2 sections on catalytic mechanisms and the Chapter 3 sections on enzyme regulation, particularly 3-0, 3-4 and 3-5.

Chapter 3 from Cell Signaling by Lim, Mayer and Pawson – Protein Interactions   New for 2007–2008
This chapter from a forthcoming title in the Primers series contains basic sections on the principles and kinetics of binding interactions that extend and supplement the coverage of binding interactions in sections 2-1, 2-3 and 2-4. Much of the content of this chapter will be included in the next edition of Protein Structure and Function.

U3-1 and U3-2 – Control by pH and Redox
The revised sections on control by pH and redox can be used to replace section 3-3.

U3-3 and U3-4 – Protein Phosphatases
The new sections on phosphatases can be used after any of the sections on eukaryotic kinases, 3-12 to 3-14.
(New for 2007–2008  Note that these sections, added in the 2004–2005 update, have been revised for the 2007–2008 update to reflect more recent developments.)