| A selection of proteins containing SH2 domains are schematically represented, showing their covalent linkage to other protein and phospholipid interaction domains (SH3, CH, PH, C1, C2), that contribute to the binding specificity of the protein, and/or to protein kinase domains, guanine nucleotide exchange factor (GEF) domains that activate Rho family GTPases (RhoGEF), GTPase activating domains that inactivate the Ras GTPase (RasGAP), phospholipase C (PLC) catalytic domains, as well as the DNA-binding (DNA-BD) domains of gene regulatory proteins. |
